Nifedipine (India)

For the management of vasospastic angina, chronic stable angina and hypertension.

Nifedipine is used as a coronary vasodilator and an antianginal in the treatment of coronary insufficiency and angina of effort. The chemical designation is 1,4-Dihydro-2,6-dimethyl-4-(2- nitrophenyl)-3,5- pyridine dicarboxylic acid, dimethyl ester; It is a yellow crystalline powder; insoluble in water , soluble in ethanol; melting point 171 - 175 C; administered orally.

Chemical IUPAC Name :dimethyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Formula: C17H18N2O6

CAS Registry Number : 21829-25-4

KEGG Compound ID : C07266

Drug ID Number [DIN] : 02235898

Molecular Weight : 346.335 g/mol
Melting Point : 172 - 174 °C
H2O: Solubility Insoluble
State: Solid
LogP/Hydrophobicity: 2.343

SALES SPECIFICATION :
APPEARANCE yellow crystalline powder
IDENTIFICATION Complies Test A,B
ASSAY (HPLC) 98.0 - 102.0%
IMPURITY 1.0% max; (Individual impurity: 0.2% max, Nitrosophenylpyridine: 0.2% max)
LOSS ON DRYING 0.5% max
CHLORIDE 0.02% max
SULFATE 0.05% max
HEAVY METALS 10ppm max
MELTING POINT 171 - 175 C